Amlodipine + Indapamide
Uses of Amlodipine + Indapamide
The combination of Amlodipine and Indapamide belongs to the class of medications known as calcium channel blockers and thiazide diuretics. It is indicated for the treatment of hypertension, aiming to lower blood pressure through dual mechanisms.
How Amlodipine + Indapamide Works
Amlodipine, a calcium channel blocker, dilates blood vessels, reducing peripheral resistance and blood pressure. Indapamide, a thiazide diuretic, increases urine production, leading to decreased blood volume and subsequent blood pressure reduction. Together, they contribute to the management of hypertension through complementary mechanisms.
Side Effects of Amlodipine + Indapamide
Dizziness, Headache, Ankle Swelling, Flushing, and Increased Blood Potassium Levels.
Warnings
Kidney High Risk
Amlodipine + Indapamide must be used with caution in patients with severe kidney disease. A dose adjustment of Amlodipine + Indapamide may be needed. It is contraindicated in patients with anuria. Please consult your doctor.
Alcohol Not Advisable
It is not advisable to consume alcohol with Amlodipine + Indapamide. Taking Amlodipine + Indapamide with alcohol may enhance the orthostatic effect of Indapamide.
Pregnancy Maybe Safe
Amlodipine + Indapamide may be safe to use during pregnancy. Animal studies have failed to show adverse effects on the fetus. However, there are limited well-controlled human studies. Please consult your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Amlodipine + Indapamide may cause side effects such as dizziness, tiredness, or palpitations, all of which could affect the ability to concentrate and drive.
Liver Limited Data
Amlodipine + Indapamide is contraindicated in patients with severe hepatic impairment. Dose adjustment of Amlodipine + Indapamide may be needed in patients with other liver diseases. Please consult your doctor.
Lactation Limited Data
Amlodipine + Indapamide must be used with caution during lactation as it is excreted in human milk. Limited human data suggests that Amlodipine + Indapamide does not represent a significant risk to the baby. Please consult your doctor.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
