Amlodipine + Indapamide + Perindopril
Uses of Amlodipine + Indapamide + Perindopril
The combination of Amlodipine, Indapamide, and Perindopril is a fixed-dose antihypertensive medication used for the treatment of hypertension, combining a calcium channel blocker (amlodipine), a diuretic (indapamide), and an angiotensin-converting enzyme (ACE) inhibitor (perindopril) to help lower blood pressure.
How Amlodipine + Indapamide + Perindopril Works
Amlodipine is a calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle cells, leading to vasodilation and decreased peripheral vascular resistance. Indapamide is a diuretic that promotes the excretion of sodium and water, reducing blood volume and lowering blood pressure. Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II, resulting in vasodilation and decreased aldosterone secretion, further lowering blood pressure. The combination of these three medications works synergistically to effectively manage hypertension.
Side Effects of Amlodipine + Indapamide + Perindopril
Dizziness, Headache, Peripheral Edema, Flushing, Cough, and Hypotension.
Warnings
Kidney High Risk
Amlodipine + Indapamide + Perindopril must be used with caution in patients with severe kidney disease. A dose adjustment of Amlodipine + Indapamide + Perindopril may be needed. It is contraindicated in patients with anuria. Please consult your doctor.
Alcohol Not Advisable
It is not advisable to consume alcohol with Amlodipine + Indapamide + Perindopril. Taking Amlodipine + Indapamide + Perindopril with alcohol may enhance the orthostatic effect of Indapamide.
Pregnancy Maybe Safe
Amlodipine + Indapamide + Perindopril may be safe to use during pregnancy. Animal studies have failed to show adverse effects on the fetus. However, there are limited well-controlled human studies. Please consult your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Amlodipine + Indapamide + Perindopril may cause side effects such as dizziness, tiredness, or palpitations, all of which could affect the ability to concentrate and drive.
Liver Limited Data
Amlodipine + Indapamide + Perindopril is contraindicated in patients with severe hepatic impairment. Dose adjustment of Amlodipine + Indapamide + Perindopril may be needed in patients with other liver diseases. Please consult your doctor.
Lactation Limited Data
Amlodipine + Indapamide + Perindopril must be used with caution during lactation as it is excreted in human milk. Limited human data suggests that Amlodipine + Indapamide + Perindopril does not represent a significant risk to the baby. Please consult your doctor.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
