Amlodipine + Perindopril

Uses of Amlodipine + Perindopril

The combination of Amlodipine and Perindopril belongs to the class of antihypertensive medications and is indicated for the treatment of hypertension.

How Amlodipine + Perindopril Works

Amlodipine, a calcium channel blocker, relaxes blood vessels by inhibiting calcium influx into vascular smooth muscle cells, leading to vasodilation. Perindopril, an angiotensin-converting enzyme (ACE) inhibitor, reduces blood pressure by blocking the conversion of angiotensin I to angiotensin II, resulting in further vasodilation and decreased aldosterone production. Together, they act synergistically to manage hypertension.

Side Effects of Amlodipine + Perindopril

Dizziness, Headache, Peripheral Edema, Flushing, Cough, and Hypotension.

Warnings

Kidney High Risk

Amlodipine + Perindopril must be used with caution in patients with severe kidney disease. A dose adjustment of Amlodipine + Perindopril may be needed. It is contraindicated in patients with anuria. Please consult your doctor.

Alcohol Not Advisable

It is not advisable to consume alcohol with Amlodipine + Perindopril. Taking Amlodipine + Perindopril with alcohol may enhance the orthostatic effect of Indapamide.

Pregnancy Maybe Safe

Amlodipine + Perindopril may be safe to use during pregnancy. Animal studies have failed to show adverse effects on the fetus. However, there are limited well-controlled human studies. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Amlodipine + Perindopril may cause side effects such as dizziness, tiredness, or palpitations, all of which could affect the ability to concentrate and drive.

Liver Limited Data

Amlodipine + Perindopril is contraindicated in patients with severe hepatic impairment. Dose adjustment of Amlodipine + Perindopril may be needed in patients with other liver diseases. Please consult your doctor.

Lactation Limited Data

Amlodipine + Perindopril must be used with caution during lactation as it is excreted in human milk. Limited human data suggests that Amlodipine + Perindopril does not represent a significant risk to the baby. Please consult your doctor.

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).