Aspirin + Clopidogrel
Uses of Aspirin + Clopidogrel
Aspirin and clopidogrel, when used in combination, belong to the class of antiplatelet agents and are indicated for the prevention of thrombotic events in patients at risk for cardiovascular disease.
How Aspirin + Clopidogrel Works
Aspirin and clopidogrel, both antiplatelet agents, act through different mechanisms to inhibit blood clot formation. Aspirin inhibits the enzyme cyclooxygenase, reducing the production of thromboxane A2 and thus preventing platelet aggregation. Clopidogrel, on the other hand, blocks the P2Y12 adenosine diphosphate (ADP) receptor on platelets, further inhibiting their activation and aggregation. Together, these drugs provide a dual antiplatelet effect, reducing the risk of thrombotic events.
Side Effects of Aspirin + Clopidogrel
Common side effects may include: Gastrointestinal disturbances (e.g., abdominal pain, dyspepsia), Bleeding events (e.g., bruising, nosebleeds), Diarrhea, Headache. DizzinessRash
Warnings
Kidney Use With Care
There is limited study on the usage of Aspirin + Clopidogrel in patients with renal impairment. This, it is recommended that Aspirin + Clopidogrel should be used with caution in such patients.
Alcohol Safe
It is safe to take alcohol with Aspirin + Clopidogrel. However, it is advisable to consume alcohol in moderate amount because drinking too much alcohol while on Aspirin + Clopidogrel might irritate the stomach.
Pregnancy Maybe Safe
Animal studies have failed to prove that there is a risk to the fetus and there are no adequate human studies. As no data is available, it is recommended not to use Aspirin + Clopidogrel during pregnancy.
Driving Generally Safe
Aspirin + Clopidogrel usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Limited Data
There is limited experience in patients with liver disease who may have bleeding tendencies. In such a population, Aspirin + Clopidogrel need to be used with caution.
Lactation Limited Data
There is limited human data on whether Aspirin + Clopidogrel is excreted in human breast milk. Animal studies demonstrated that Aspirin + Clopidogrel is excreted in breast milk. It is advisable that breastfeeding is discontinued following treatment with Aspirin + Clopidogrel.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
