Atovaquone + Proguanil
Uses of Atovaquone + Proguanil
This combination is classified as an antimalarial medication, indicated for the prevention and treatment of malaria.
How Atovaquone + Proguanil Works
Atovaquone and proguanil work synergistically to inhibit different stages of the malaria parasite's life cycle. Atovaquone interferes with the parasite's mitochondrial electron transport, while proguanil inhibits the parasite's dihydrofolate reductase. Together, they provide an effective defense against Plasmodium species causing malaria.
Side Effects of Atovaquone + Proguanil
Common side effects may include stomach pain, nausea, vomiting, and headache. Serious side effects such as allergic reactions, liver problems, or blood disorders are rare but should be reported to a healthcare professional promptly.
Warnings
Kidney Limited Data
Limited data are available regarding the impact of this medication on kidney function. Consultation with a healthcare professional is recommended for individuals with kidney issues.
Alcohol Limited Data
Limited data are available regarding the interaction of this medication with alcohol. Caution is advised, and it is recommended to consult with a healthcare professional before combining the two.
Pregnancy Not Safe - High Risk
This medication is considered not safe during pregnancy due to potential risks. Alternative options or careful evaluation by a healthcare provider are essential.
Driving Use With Care
Caution is advised when operating machinery or driving, as this medication may cause dizziness or fatigue. Individual responses may vary, and it is essential to assess one's reaction before engaging in activities requiring alertness.
Liver Limited Data
Limited data are available on the effects of this medication on liver function. Caution is advised, and regular monitoring may be recommended, especially for individuals with pre-existing liver conditions.
Lactation Limited Data
Limited data are available regarding the safety of this medication during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
