Azelaic Acid
Uses of Azelaic Acid
Azelaic Acid is commonly used to treat Acne Vulgaris, Rosacea
How Azelaic Acid Works
Azelaic Acid is an aliphatic dicarboxylic acid that works by inhibiting the growth of Propionibacterium acnes. It also reduces keratinisation leading to restriction of comedones development.
Side Effects of Azelaic Acid
Burning, pain and pruritus Rash, paraesthesia, swelling and dryness
Warnings
Kidney Safe If Prescribed
Dose adjustment of Azelaic Acid is unlikely in patients with renal impairment due to low systemic absorption.
Alcohol Not Advisable
It is unsafe to consume alcohol with Azelaic Acid as alcohol may provoke inflammation at the application area leading to intense erythema.
Pregnancy Maybe Safe
Azelaic Acid should be used with caution in pregnant woman. Any harmful effects on fetal development are not indicated in animal studies. There are limited studies on human showing any adverse effect.
Driving Generally Safe
Azelaic Acid has no influence on the ability to drive.
Liver Limited Data
Due to low systemic absorption, dose adjustment of Azelaic Acid is unlikely in patients with liver impairment.
Lactation Limited Data
It is not known if Azelaic Acid is secreted into human milk in vivo. Hence, Azelaic Acid should be used with caution when it is administered to a lactating woman
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
