Bumetanide
Uses of Bumetanide
Bumetanide is commonly used to treat Oedema
How Bumetanide Works
Bumetanide works by inhibiting the absorption of sodium and chloride ions in the kidney. As a result, water will follow sodium and chloride to be excreted into the urine, thus relieving the oedema symptoms.
Side Effects of Bumetanide
Abdominal pain, Nausea, Vomiting, Headache, Diarrhea, Dehydration, Skin rash, Itchiness, Painful breast, Breast enlargement
Warnings
Kidney Use With Care
In people with renal impairment, dosage adjustment may be required. In severe renal impairment, larger doses are needed to achieve similar therapeutic effect and should be under constant monitoring.
Alcohol Safe
There is no contraindication nor any pervious data to suggest interaction between Bumetanide and alcohol. The side effects profile of Bumetanide also does not suggest any augmentation of the alcohol side effects.
Pregnancy Not Safe
Animal studies have shown some adverse reaction on the reproduction while there is no human pregnancy data to dismiss the possibility of side effects to the fetal or mother using Bumetanide. Doctor's advice should be sought before using Bumetanide in pregnancy.
Driving Generally Safe
Bumetanide has no known effect on the ability to drive or operate machinery.
Liver Limited Data
Bumetanide may precipitate encephalopathy in hepatic impaired patient. Dosage adjustment may be needed as well as close monitoring.
Lactation Limited Data
There is no data to indicate any traces of Bumetanide in the human breastmilk. It is advisable to stop using Bumetanide when the mother want to breastfeed the infant unless it is necessary.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
