Carbidopa + Entacapone + Levodopa

Uses of Carbidopa + Entacapone + Levodopa

This medication is indicated for the treatment of Parkinson's disease, belonging to the class of dopamine agonists, aiming to alleviate symptoms associated with the condition.

How Carbidopa + Entacapone + Levodopa Works

Carbidopa enhances the effectiveness of levodopa by preventing its breakdown in the bloodstream, allowing more levodopa to enter the brain and be converted to dopamine. Entacapone prolongs levodopa's effect by inhibiting an enzyme that breaks it down in the body, thus increasing dopamine levels in the brain. Levodopa is converted into dopamine in the brain, supplementing the deficiency of dopamine in Parkinson's disease.

Side Effects of Carbidopa + Entacapone + Levodopa

Common side effects may include nausea, vomiting, dizziness, and hallucinations. Less common but serious side effects can include dyskinesias, confusion, and orthostatic hypotension.

Warnings

Kidney Limited Data

Limited data are available regarding the impact of this medication on kidney function. Consultation with a healthcare professional is recommended for individuals with kidney issues.

Alcohol Limited Data

Limited data are available regarding the interaction of this medication with alcohol. Caution is advised, and it is recommended to consult with a healthcare professional before combining the two.

Pregnancy Limited Data

There is limited data on the safety of this medication during pregnancy. Consultation with a healthcare provider is recommended to assess potential risks and benefits.

Driving Use With Care

Caution is advised while driving or operating machinery, as this medication may cause dizziness or hallucinations. It is essential to assess individual response before engaging in activities that require alertness.

Liver Limited Data

Limited data are available on the effects of this medication on liver function. Caution is advised, especially for individuals with liver conditions. Consultation with a healthcare professional is recommended.

Lactation Limited Data

Limited data are available regarding the safety of this medication during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).