Dabigatran Etexilate
Uses of Dabigatran Etexilate
Dabigatran Etexilate is commonly use in the treatment of deep Vein Thrombosis, Pulmonary Embolism and nonvalvular atrial fibrillation. It is also use in prophylaxis of stroke, deep vein thrombosis and pulmonary embolism.
How Dabigatran Etexilate Works
Dabigatran is a thrombin inhibitor. It inhibits both free and fibrin-bound thrombin leading to inhibition of coagulation. It prevents the conversion of fibrinogen to fibrin, activation of factors V, VIII, XI, and XIII, and inhibition of thrombin-induced platelet aggregation.
Side Effects of Dabigatran Etexilate
Low red cell count (Anaemia), Bleeding nose (Epistaxis), Gastrointestinal bleeding, Abdominal pain, Diarrhea, Indigestion (dyspepsia), Nausea and vomiting, Blood in urine
Warnings
Kidney Use With Care
Dabigatran Etexilate should not be used in patients with severe kidney disease. Dose adjustment of Dabigatran Etexilate is required in mild to moderate kidney disease. Please consult your doctor
Alcohol Safe
It is safe to consume alcohol with dabigatran as there is no interaction between them.
Pregnancy Not Safe
Dabigatran Etexilate may be unsafe to use during pregnancy due to the results from animal studies that have shown adverse effects on the fetus. Nevertheless, there is limited evidence from human studies. The usage in pregnant women may be acceptable if the benefits outweigh the risks. Please consult your doctor.
Driving Generally Safe
Dabigatran Etexilate has no effect on the ability to drive.
Liver Limited Data
In severe liver disease with reduced survival rate, Dabigatran Etexilate is contraindicated.
Lactation Limited Data
There is no information about excretion of Dabigatran Etexilate in human milk. Therefore, Dabigatran Etexilate should be discontinued in lactating women.