Dexchlorpheniramine
Uses of Dexchlorpheniramine
Dexchlorpheniramine is commonly used to treat allergic conditions, morning sickness, motion sickness, vertigo and used as an appetite stimulant.
How Dexchlorpheniramine Works
Dexchlorpheniramine is an antihistamine. It works by inhibiting histamine H1-receptor that presents in the gastrointestinal, respiratory tract and blood vessels, thus prevents the release of histamine and other inflammatory mediators in people with allergies, motion and morning sickness.
Side Effects of Dexchlorpheniramine
Dermatitis, Sedation, CNS depression, Psychomotor impairment, Headache, Palpitations, Convulsions, Sweating, Tremor, Myalgia, Sleep disturbance, Abdominal disturbance
Warnings
Kidney Use With Care
Dexchlorpheniramine should be used with caution in patients with kidney disease. 22% of consumed Dexchlorpheniramine is excreted unchanged in the urine. Renal impairment will cause the drugs accumulate in the body which caused unwanted toxicity. Please consult your doctor.
Alcohol Not Advisable
Taking Dexchlorpheniramine with alcohol may have additive effects in worsening the side effects such as headache and dizziness.
Pregnancy Maybe Safe
Dexchlorpheniramine may be unsafe to use during pregnancy. There are limited studies to show the teratogenic risk of Dexchlorpheniramine in both animal and pregnant women. However, there is data observed that use of Dexchlorpheniramine causes irritability or sedation towards the newborn. Do not consume Dexchlorpheniramine before consulting with your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Dexchlorpheniramine may cause side effects such as dizziness, headaches, and psychomotor impairment, all of which could affect your ability to concentrate and drive.
Liver Use With Care
Dexchlorpheniramine should be used with caution in patients with liver disease. Dexchlorpheniramine metabolised in the liver by a specific enzyme, CYP450. Liver impairment will affect the pharmacokinetics of Dexchlorpheniramine and lead to unwanted side effects. Dose adjustment of Dexchlorpheniramine may be needed. Please consult your doctor.
Lactation Not Advisable
Dexchlorpheniramine can reduce lactation and may be secreted in breastmilk. Dexchlorpheniramine is contraindicated in newborn and infant which can cause irritability and sedation. Please consult your doctor.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
