Entacapone
Uses of Entacapone
Entacapone is commonly used to treat Parkinson's Disease
How Entacapone Works
Entacapone is an catechol-O-methyl transferase (COMT) inhibitors given in combination with levodopa as inhibiting the COMT enzyme in the peripheral tissues decreases the conversion of levodopa to 3-O-methyldopa (3-OMD) and leads to higher availability and clinical response of levodopa for the brain.
Side Effects of Entacapone
Nausea, Vomiting, Abdominal pain, Constipation, Diarrhea, Dry mouth, Insomnia, Dyskinesia, Parkinsonism, Dizziness, Somnolence, Dystonia, Hyperkinesia, Urine discoloration, Ischaemic heart disease
Warnings
Kidney Safe If Prescribed
The excretion of Entacapone is not affected in patients with kidney disease unless they are on dialysis. Dose adjustment is not indicated in patients with kidney disease without dialysis. Please consult your doctor before using it.
Alcohol Not Advisable
It is unsafe to consume alcohol with Entacapone because Alcohol can exaggerate the nervous system side effects of Entacapone such as dizziness and dyskinesia.
Pregnancy Not Safe
Entacapone may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may outweigh the risk. Please consult your doctor before using it.
Driving Not advisable
Entacapone may cause side effects such as dizziness and somnolence all of which could affect your ability to concentrate and drive. Do not drive unless you're feeling well.
Liver Limited Data
Entacapone should be used with caution in patients with liver disease. Dose adjustment of Entacapone may be needed. Please consult your doctor before using it.
Lactation Limited Data
Entacapone is excreted into the breastmilk during animal studies. However, its effect on feeding infants is largely unknown. Hence, Entacapone is not recommended for use in breastfeeding women.