Ezetimibe

Uses of Ezetimibe

Ezetimibe is commonly used to treat patients with high cholesterol levels.

How Ezetimibe Works

Ezetimibe treats patients with high cholesterol levels by inhibiting the absorption of cholesterol via the sterol transporter, NPC1L1. As a result, it decreased levels of cholesterol in the liver, reduced the hepatic cholesterol storage and increased clearance of cholesterol from the blood.

Side Effects of Ezetimibe

Headache, Myalgia, Abdominal pain, Diarrhea, Fatigue, Chest pain, Rash

Warnings

Kidney Use With Care

Ezetimibe should be used with caution in patients with severe kidney disease. Dose adjustment of Ezetimibe may be needed. Please consult your doctor.

Alcohol Safe

It is safe to consume Ezetimibe with alcohol.

Pregnancy Not Safe

Ezetimibe may be unsafe to use during pregnancy. Animal studies have shown side effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable even with the risk. Please consult your doctor.

Driving Generally Safe

Ezetimibe usually does not affect the ability to drive. Do not drive unless you are feeling well.

Liver Limited Data

Ezetimibe is not recommended in patients with moderate and severe liver disease; Child Pugh Score > 7. Please consult your doctor.

Lactation Limited Data

No academic reports explaining the use of Ezetimibe for breastfeeding mothers have been located. However, if Ezetimibe is taken by breastfeeding mothers, the nursing infant should be closely monitored for any adverse reactions.

Frequently Asked Questions

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).