Hydrochlorothiazide + Irbesartan

Uses of Hydrochlorothiazide + Irbesartan

Hydrochlorothiazide + Irbesartan is classified as an angiotensin II receptor antagonist and thiazide diuretic combination indicated for the treatment of hypertension.

How Hydrochlorothiazide + Irbesartan Works

Hydrochlorothiazide works by reducing the reabsorption of sodium and water in the kidneys, leading to increased urine production and decreased blood volume, thereby lowering blood pressure. Irbesartan blocks the action of angiotensin II, a substance in the body that causes blood vessels to constrict, resulting in the relaxation and widening of blood vessels, further lowering blood pressure.

Side Effects of Hydrochlorothiazide + Irbesartan

Common side effects may include dizziness, headache, fatigue, and gastrointestinal disturbances. Less common but serious side effects may include allergic reactions, electrolyte imbalances, and kidney dysfunction.

Warnings

Kidney Limited Data

Limited data are available regarding the impact of this medication on kidney function. Consultation with a healthcare professional is recommended for individuals with kidney issues.

Alcohol Limited Data

Limited data are available regarding the interaction of this combination with alcohol. Caution is advised, and consultation with a healthcare professional is recommended before combining the two.

Pregnancy Limited Data

There is limited data on the safety of this combination during pregnancy. Consultation with a healthcare provider is recommended to assess potential risks and benefits.

Driving Use With Care

Caution is advised while driving or operating machinery, as this combination may cause dizziness or blurred vision. It is essential to assess individual response before engaging in activities that require alertness.

Liver Limited Data

Limited data are available on the effects of this combination on liver function. Caution is advised, especially in patients with liver conditions. Consultation with a healthcare professional is recommended.

Lactation Limited Data

Limited data are available regarding the safety of this combination during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).