Lopinavir + Ritonavir
Uses of Lopinavir + Ritonavir
Lopinavir + Ritonavir belongs to the class of protease inhibitors and is indicated for the treatment of HIV-1 infection in adults and pediatric patients.
How Lopinavir + Ritonavir Works
This medication works by inhibiting the HIV protease enzyme, thereby blocking the cleavage of viral polyproteins and preventing the formation of mature infectious virus particles, ultimately suppressing viral replication.
Side Effects of Lopinavir + Ritonavir
Common side effects may include nausea, vomiting, diarrhea, and headache. Serious side effects can include liver problems, pancreatitis, and changes in heart rhythm.
Warnings
Kidney Limited Data
Limited data are available regarding the impact of this medication on kidney function. Consultation with a healthcare professional is recommended for individuals with kidney issues.
Alcohol Limited Data
Limited data are available regarding the interaction of this combination with alcohol. Caution is advised, and consultation with a healthcare professional is recommended before combining the two.
Pregnancy Limited Data
There is limited data on the safety of this combination during pregnancy. Consultation with a healthcare provider is recommended to assess potential risks and benefits.
Driving Generally Safe
This medication is generally considered safe for driving, but individual responses may vary. It is advisable to assess personal reaction before engaging in activities requiring alertness.
Liver High Risk
This medication carries a high risk of liver problems and should be used with extreme caution, especially in individuals with pre-existing liver conditions. Consultation with a healthcare provider is crucial before use.
Lactation Limited Data
Limited data are available regarding the safety of this combination during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
