Megestrol
Uses of Megestrol
Megestrol is commonly used to treat breast cancer, endometrial cancer and to overcome severe weight loss and loss of appetite in patients with HIV.
How Megestrol Works
Megestrol is a synthetic progestogen used as an antineoplastic and appetite stimulant. Through its antiestrogenic properties inhibition, it is indicated for certain hormone- dependent neoplasms, such as breast cancer. It has glucocorticoid effect but a very slight mineralocorticoid effect.
Side Effects of Megestrol
Weight gain, Constipation, Urinary frequency, Cushing's syndrome, Cushingoid, Increased blood sugar, Increased appetite, Mood lability, Hot flush, Increased blood pressure, Difficulty breathing, Rash, Menorrhagia, Erectile dysfunction, Tumor flare
Warnings
Kidney Use With Care
Megestrol should be used with caution in patients with kidney disease. Dose adjustment of Megestrol may be needed. Please consult your doctor before using it.
Alcohol Safe
Consuming alcohol in moderation doesn't cause the disturbance to pharmacokinetics of Megestrol. However, please consult your doctor before using it.
Pregnancy Not Safe - High Risk
Megestrol in oral suspension form may be unsafe to use during pregnancy due to proven foetal abnormalities in animal and human studies. Megestrol in oral tablet form may have shown adverse effects on the fetus, however, benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor before using it.
Driving Generally Safe
Megestrol may cause minimal to no side effects which could affect your ability to concentrate and drive.
Liver Use With Care
Megestrol should be used with caution in patients with kidney disease. Dose adjustment of Megestrol may be needed. Please consult your doctor before using it.
Lactation Not Advisable
Due to potential adverse effects of Megestrol, it is probably not safe to use during lactation. Please consult your doctor before using it.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
