Metformin + Sitagliptin

Uses of Metformin + Sitagliptin

This medication is a combination of a biguanide (Metformin) and a dipeptidyl peptidase-4 (DPP-4) inhibitor (Sitagliptin), belonging to the class of antidiabetic agents. It is indicated for the management of type 2 diabetes mellitus.

How Metformin + Sitagliptin Works

Metformin decreases glucose production in the liver and improves insulin sensitivity in muscle and fat tissues. Sitagliptin works by increasing levels of incretin hormones, which stimulate insulin release in response to meals and decrease the amount of glucose produced by the liver.

Side Effects of Metformin + Sitagliptin

Common side effects may include gastrointestinal upset, such as diarrhea, nausea, or stomach discomfort. Less common but serious side effects may include lactic acidosis or pancreatitis. Consult a healthcare professional if any severe side effects occur.

Warnings

Kidney Safe If Prescribed

This medication is considered safe if prescribed for individuals with kidney issues. However, dosage adjustments may be necessary based on renal function.

Alcohol Limited Data

Limited data are available regarding the interaction of this combination with alcohol. Caution is advised, and consultation with a healthcare professional is recommended before combining the two.

Pregnancy Limited Data

There is limited data on the safety of this medication during pregnancy. Consultation with a healthcare provider is recommended.

Driving Generally Safe

This medication is generally safe to use while driving or operating machinery. However, individuals should monitor their blood glucose levels regularly to ensure they are not experiencing hypoglycemia, which can affect driving ability.

Liver Limited Data

Limited data are available on the effects of this medication on liver function. Caution is advised, especially for individuals with liver conditions. Consultation with a healthcare professional is recommended.

Lactation Limited Data

Limited data are available regarding the safety of this combination during lactation. Consultation with a healthcare professional is advised to determine potential risks and benefits.

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).