Methyldopa
Uses of Methyldopa
Methyldopa is commonly used to treat Hypertension
How Methyldopa Works
Methyldopa works by stimulating the central alpha-adrenergic receptor which results in reduce sympathetic tone and lowering the blood pressure.
Side Effects of Methyldopa
Drowsiness, Headache, Low blood pressure, Weakness, Fatigue, Disturbed sleep, Impotence, Nausea, Vomiting
Warnings
Kidney Use With Care
Dosage adjustment may be needed for patients with renal impairment with lower doses.
Alcohol Safe
There is no clear contraindication on the consumption of alcohol when taking Methyldopa.
Pregnancy Not Safe
Methyldopa crosses placenta but according to human pregnancy data, it is safe to be used as there were no fetal harm or toxicity reported.
Driving Not advisable
It is not advisable to drive when under Methyldopa treatment due to its potential side effects such as fatigue, headache and dizziness which can affect the ability to concentrate and drive.
Liver Safe If Prescribed
Methyldopa should be used with caution and close monitoring is advisable for patients with hepatic impairment. It is contraindicated in those with active liver disease.
Lactation Safe If Prescribed
The metabolites of Methyldopa been detected in human breastmilk and thus it should be used with caution during breastfeeding only if the benefits outweigh the risks.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
