Olaparib

Uses of Olaparib

Olaparib is commonly used to treat Ovarian Cancer, fallopian tube cancer, primary peritoneal cancer and breast cancer.

How Olaparib Works

Olaparib inhibits poly ADP-ribose polymerase (PARP) enzymes, which are essential in the repair, regulation and formation of DNA in cancer cells. Inhibition causes formation of double stranded DNA breaks which cannot be repaired thereby leading to cell apoptosis in tumour cells.

Side Effects of Olaparib

Nausea, Vomiting, Diarrhea, Dyspepsia, Fatigue, Headache, Distorted sense of taste, Decreased appetite, Dizziness, Upper abdominal pain, Cough, Difficulty breathing, Low red blood cell count, Low white cell blood cell count, Low platelet count

Warnings

Kidney Use With Care

Olaparib should be used with caution in patients with mild to moderate kidney disease. Dose adjustment of Olaparib may be needed. Please consult your doctor before using it. Use of Olaparib is not recommended in patients with severe kidney disease.

Alcohol Safe

Consuming alcohol in moderation doesn't cause the disturbance to pharmacokinetics of Olaparib. However, please consult your doctor before using it.

Pregnancy Not Safe

Olaparib may be unsafe to use during pregnancy. Human studies have shown adverse effects on the fetus, however, the benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor before using it.

Driving Not advisable

Olaparib may cause side effects of dizziness, headaches and fatigue, all of which could affect your ability to concentrate and drive. Do not drive unless you are feeling well.

Liver Use With Care

Olaparib should be used with caution in patients with mild to moderate liver disease. Dose adjustment of Olaparib may be needed. Please consult your doctor before using it. Use of Olaparib is not recommended in patients with severe liver disease.

Lactation Not Advisable

Olaparib is excreted in breastmilk of animal studies but it is inconclusive in human studies. However, given its pharmacologic therapy, Olaparib is not recommended for use during breastfeeding. Please consult your doctor before using it.

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).