Orlistat
Uses of Orlistat
Orlistat is commonly used to treat obesity.
How Orlistat Works
Orlistat inhibits the absorption of dietary fats through the formation of a covalent bond with the active serine residue site of the pancreatic and gastric lipases. This will prevent the hydrolysis of dietary fat in the form of triglycerides into absorbable free fatty acids and monoglycerides.
Side Effects of Orlistat
Flatulence, Fecal incontinence, Fatty stools or discharge, Headache, Anxiety, Fatigue, Urinary tract infection, Menstrual disturbances.
Warnings
Kidney Use With Care
It is recommended to use Orlistat with caution in patients with renal impairment because the safety profile has not been studied.
Alcohol Safe
It is safe to consume alcohol while taking Orlistat. There are no changes in alcohol pharmacokinetics, Orlistat pharmacodynamics or systemic exposure to Orlistat.
Pregnancy Not Safe - High Risk
Both human and animal studies have reported fetal abnormalities and the risks to fetus clearly outweigh potential benefits to the mother. Orlistat is contraindicated in pregnancy because the weight loss may cause harm to the fetus.
Driving Generally Safe
Orlistat usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Limited Data
It is recommended to use Orlistat with caution in patients with liver impairment because the safety profile has not been studied.
Lactation Limited Data
It remained unknown whether Orlistat is excreted in human breast milk, therefore it is recommended to avoid the usage of Orlistat during breastfeeding.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
