Oxcarbazepine
Uses of Oxcarbazepine
Oxcarbazepine is commonly used to treat partial seizures and/or generalized tonic-clonic seizures.
How Oxcarbazepine Works
The mechanism of action of oxcarbazepine is based on the blockade of voltage-sensitive sodium channels, thus stabilizing as well as inhibiting disorganized neuronal firing and the diminishing of propagation of synaptic impulses. It also increases potassium conductance and modulation of high-voltage activated calcium channels.
Side Effects of Oxcarbazepine
Somnolence, Headache, Dizziness, Diplopia, Nausea, Vomiting, Fatigue, Increased weight, Hyponatremia
Warnings
Kidney Use With Care
Oxcarbazepine should be used with caution in patients with kidney disease. Dose adjustment of Oxcarbazepine may be needed. Please consult your doctor before using it.
Alcohol Not Advisable
It is unsafe to consume alcohol with Oxcarbazepine as it can potentiate the sedative effects of the medication.
Pregnancy Not Safe
Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor before using it.
Driving Not advisable
Oxcarbazepine may cause side effects such as dizziness, headache, nausea or tiredness, all of which could affect your ability to concentrate and drive. Do not drive unless you are feeling well.
Liver Use With Care
Oxcarbazepine should be used with caution in patients with mild to moderate liver disease. Dose adjustment of Oxcarbazepine may be needed. Please consult your doctor before using it. There's insufficient data on the usage of Oxcarbazepine in severe liver disease.
Lactation Not Advisable
Oxcarbazepine is excreted into human breast milk. However, its adverse effect on the feeding baby is largely unknown. Please consult your doctor before using it.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
