Papain
Uses of Papain
Papain is commonly used to treat oedema and inflammation.
How Papain Works
Papain also known as papaya proteinase I, is a cysteine protease enzyme that is found in species of papaya, Carica papaya and Vasconcellea cundinamarcensis. When topically applied, papain induces an allergen-like inflammatory response by recruiting neutrophils, mast cells, and CD3-positive cells and by induction of a TH2-biased antibody response.
Side Effects of Papain
Urticaria, Pruritus, Dizziness, Nausea, Vomiting, Diarrhea, Sensitisation,
Warnings
Kidney Use With Care
Due to limited data, Papain should be used with caution in patients with kidney disease. Dose adjustment of Papain may be needed. Please consult your doctor before using it.
Alcohol Limited Data
Certain food and medications will have interactions with concurrent use of Papain but there is no specific data stating so. Please consult your doctor before using it.
Pregnancy Limited Data
Papain is not indicated for usage during pregnancy. Since animal studies or human studies have not shown adverse effects on the fetus, please consult your doctor before using it.
Driving Limited Data
Papain's side effects on your ability to concentrate and drive is unknown. Do not drive unless you are feeling well.
Liver Limited Data
Due to limited data, Papain should be used with caution in patients with liver disease. Dose adjustment of Papain may be needed. Please consult your doctor before using it.
Lactation Limited Data
Papain excretion into breast milk and its effect on feeding baby is still unknown. Please discuss with your doctor before using it.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
