Pioglitazone
Uses of Pioglitazone
Pioglitazone is commonly used in treatment of Type 2 Diabetes Mellitus.
How Pioglitazone Works
Pioglitazone is peroxisome proliferator-activated receptor-alpha� (PPAR-alpha�) agonist. It activates this receptor and promotes the production of products involved in lipid and glucose metabolism. It also improves the response of insulin on target cells.
Side Effects of Pioglitazone
Weight gain, Sinusitis, Edema, Upper Respiratory Tract Infections, Visual disturbances, Abnormal Liver Function Test
Warnings
Kidney Safe If Prescribed
No dose adjustment needed in a patient with kidney impairment.
Alcohol Not Advisable
It is not recommended to take alcohol with this medication as alcohol may affect blood glucose levels.
Pregnancy Not Safe
Limited data is available on the safety of Pioglitazone in human pregnancy. Studies in animals show fetal growth restriction with administration of this medication. Therefore, Pioglitazone is not recommended to be used in pregnancy unless the benefits outweigh the risks.
Driving Generally Safe
Pioglitazone has not shown to cause impairment in the ability to drive or operate machines. However, as it may cause visual disturbance, patients experiencing this side effect should be cautious and only drive when feeling well.
Liver Limited Data
Pioglitazone should not be used in a patient with liver impairment.
Lactation Limited Data
Studies have shown that Pioglitazone is excreted in the breastmilk of lactating rats. However, no data is available on human milk. Therefore this medication is not recommended in breastfeeding mothers.