Riluzole
Uses of Riluzole
Riluzole is commonly used to treat Amyotrophic Lateral Sclerosis (ALS)
How Riluzole Works
The mechanism of Riluzole is unknown to date. It is postulated that its inhibitory effect on the glutamate release is able to slow the disease progression and improve the survival rate of patients suffering from ALS.
Side Effects of Riluzole
Decreased white blood cells, Dizziness, Drowsiness, Vertigo, Tachycardia, Perioral numbness, Diarrhea, Abdominal pain, Allergic reaction, Liver dysfunction, Headache, Interstitial lung disease
Warnings
Kidney High Risk
Riluzole is contraindicated in patients with kidney impairment. Please consult your doctor.
Alcohol Not Advisable
Alcohol may further damage the liver which is one of the side effects of Riluzole. Thus, it is not advisable to consume alcohol with Riluzole concomitantly.
Pregnancy Limited Data
There are limited data on the use of Riluzole in pregnant women and safety profile has not been established. Thus, it is contraindicated during pregnancy. Please consult your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Riluzole may cause side effects such as drowsiness, dizziness or vertigo, all of which could affect your ability to concentrate and drive.
Liver Use With Care
Riluzole is contraindicated in patients with liver impairment. Please consult your doctor.
Lactation Not Advisable
There are limited data on the use of Riluzole in breastfeeding women and safety profile has not been established. Thus, it is contraindicated during breastfeeding.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
