Ritonavir
Uses of Ritonavir
Ritonavir is commonly used to treat HIV Infection
How Ritonavir Works
Ritonavir is an HIV protease inhibitor that will disrupt the production of proteins and enzymes of the HIV so the functionality and activity of HIV are impeded.
Side Effects of Ritonavir
Gut disturbances, Taste disturbances, Headache, Perioral/Limbs numbness, Insomnia, Skin rash, Weight loss, Immune reconstitution syndrome, Increased triglyceride and cholesterol level, Hyperglycaemia, Pancreatitis, Liver dysfunction
Warnings
Kidney Safe If Prescribed
Ritonavir is safe to be used in patients with kidney impairment.
Alcohol Not Advisable
Alcohol may accentuate the liver damage caused by Ritonavir. Thus, it is not advisable to consume alcohol and Ritonavir concomitantly.
Pregnancy Maybe Safe
Animal studies have shown reproductive toxicities but human studies have not shown any reproductive toxicities. Thus, Ritonavir can be used during pregnancy if needed.
Driving Generally Safe
Ritonavir usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
No dose adjustment needed for patients with mild to moderate liver impairment. However, Ritonavir is contraindicated in patients with severe liver impairment. Please consult your doctor.
Lactation Not Advisable
Excretion of Ritonavir is found in human breast milk but there is no information on the effects of Ritonavir on breastfed babies. An HIV-infected woman should not breastfeed to prevent HIV transmission, developing viral resistance and serious side effects onto the breastfed babies. Please consult your doctor.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
