Roflumilast
Uses of Roflumilast
Roflumilast is commonly used to treat Chronic Obstructive Pulmonary Disease (COPD)
How Roflumilast Works
Roflumilast is a phosphodiesterase-4 inhibitor which has anti-inflammatory and anti-modulatory effects in the lungs. Thus, it is able to help to improve the severity of COPD.
Side Effects of Roflumilast
Weight loss, Anxiety, Insomnia, Abdominal pain, Nausea, Diarrhea, Decreased appetite, Back pain, Headache, Dizziness
Warnings
Kidney Safe If Prescribed
Roflumilast is safe to be used in patients with kidney impairment.
Alcohol Not Advisable
There is no known interaction between alcohol and Roflumilast when consumed concomitantly. However, alcohol is not advisable for a patient with COPD as it will worsen the condition.
Pregnancy Not Safe
Animal studies have shown reproductive toxicities but there are limited data on the use of Roflumilast in pregnant women. Thus, it is not advisable to be used during pregnancy.
Driving Generally Safe
Roflumilast usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
Dose adjustment is needed in patients with mild liver impairment. Roflumilast is contraindicated in patients with moderate to severe liver impairment.
Lactation Not Advisable
Excretion of Roflumilast has been found in animal milk but it is unknown in human breast milk. Thus, it is not advisable to be used during breastfeeding as risks cannot be excluded.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
