Sacubitril + Valsartan
Uses of Sacubitril + Valsartan
Sacubitril and Valsartan, an ARB (angiotensin receptor blocker) and neprilysin inhibitor combination, is used to treat heart failure with reduced ejection fraction (HFrEF).
How Sacubitril + Valsartan Works
Sacubitril inhibits neprilysin, leading to increased levels of natriuretic peptides, which promote vasodilation and natriuresis. Valsartan blocks angiotensin II receptors, preventing vasoconstriction and aldosterone secretion. Together, they reduce strain on the heart and improve cardiac function.
Side Effects of Sacubitril + Valsartan
Common side effects include hypotension, hyperkalemia, and renal impairment. Less common but serious side effects can include angioedema and severe hypotension.
Warnings
Kidney Use With Care
Use with caution in patients with renal impairment; monitor kidney function regularly.
Alcohol Use With Care
Alcohol may enhance the blood pressure-lowering effect of this medication; caution is advised when consuming alcohol.
Pregnancy Not Safe - High Risk
This medication can cause harm to the fetus and should not be used during pregnancy.
Driving Use With Care
May cause dizziness or hypotension; assess individual response before driving or operating machinery.
Liver Use With Care
Caution is advised when prescribing to patients with liver impairment; liver function should be monitored regularly.
Lactation Limited Data
Limited data are available regarding the safety of this medication during lactation. Consultation with a healthcare professional is advised.