Silodosin
Uses of Silodosin
Silodosin is commonly used to treat Benign Prostatic Hyperplasia
How Silodosin Works
Silodosin is a selective alpha-1-adrenergic receptor inhibitor which is able to block the receptors located in the prostate, urethra and bladder trigone, leading to smooth muscle relaxation and improve the urine flow in individuals with benign prostatic hyperplasia.
Side Effects of Silodosin
Postural hypotension, Tachycardia, Diarrhea, Abdominal pain, Dry mouth, Dizziness, Headache, Insomnia, Urinary tract infection, Abnormal ejaculation, Decreased libido, Nasal congestion
Warnings
Kidney Use With Care
Dose adjustment is needed in patients with moderate kidney impairment. It is contraindicated in patients with severe kidney impairment (Creatinine clearance <30ml/min).
Alcohol Not Advisable
Alcohol may further lower the blood pressure causing dizziness or feeling of fainting when consumed concomitantly with Silodosin. Thus, it is not advisable to consume alcohol and Silodosin.
Pregnancy Maybe Safe
Silodosin has no therapeutic indication in women.
Driving Not advisable
Do not drive unless you are feeling well. Silodosin may cause side effects such as dizziness, headaches or fainting, all of which could affect your ability to concentrate and drive.
Liver Limited Data
Dose adjustment is needed in patients with mild to moderate liver impairment. It is contraindicated in patients with severe liver impairment.
Lactation Limited Data
Silodosin has no therapeutic indication in women.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
