Solifenacin
Uses of Solifenacin
Solifenacin is commonly used to treat Overactive Bladder (OAB) Symptoms.
How Solifenacin Works
Solifenacin is a competitive muscarinic receptor inhibitor which has a higher affinity for the muscarinic receptors in the detrusor muscle of the bladder. It helps to prevent smooth muscle contraction of the bladder to relieve the symptoms of overactive bladder disease.
Side Effects of Solifenacin
Constipation, Heartburn, Nausea, Abdominal pain, Hypertension, Oedema, Headache, Fatigue, Urinary tract infection, Blurred vision
Warnings
Kidney Use With Care
No dose adjustment needed for patients in mild to moderate kidney impairment. However, caution use has to be practised in patients with severe kidney impairment (creatinine clearance less than 30ml/min). Please consult your doctor.
Alcohol Safe
There is no known interaction between alcohol and Solifenacin when used concomitantly.
Pregnancy Not Safe
Animal studies have not shown any reproductive toxicities and there are no data on the use of Solifenacin in pregnant women. Thus, it is not advisable to be used unless clearly indicated. Please consult your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Solifenacin may cause side effects such as blurring of vision, sleepiness or tiredness, all of which could affect your ability to concentrate and drive.
Liver Use With Care
No dose adjustment needed for patients in mild liver impairment. However, caution use has to be practised in patients with moderate to severe liver impairment. Please consult your doctor.
Lactation Not Advisable
Excretion of Solifenacin has been found in animal milk and caused negative effects on breastfed animal. However, there are no data on the excretion of Solifenacin in human breastmilk. Thus, it is not advisable to be used during breastfeeding.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
