Tofacitinib
Uses of Tofacitinib
Tofacitinib is commonly used to treat Psoriatic Arthritis, Rheumatoid Arthritis, Ulcerative Colitis
How Tofacitinib Works
Tofacitinib is a partial janus kinase (JAK) inhibitor that can reversibly inhibit the janus kinase-signal transducers and activators of transcription pathway which involves in haematopoiesis and immune cell function. Thus, it can help to reduce the inflammatory response in autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis and ulcerative colitis.
Side Effects of Tofacitinib
Opportunistic infections, Anaemia, Headache, Hypertension, Cough, Abdominal pain, Nausea and vomiting, Diarrhea, Rash, Fever
Warnings
Kidney Use With Care
Dose adjustment is needed in patients with severe kidney impairment.
Alcohol Safe
There is no known interaction between alcohol and Tofacitinib when used concomitantly.
Pregnancy Not Safe
Animal studies have shown reproductive toxicities but there are limited data and well-controlled human studies on pregnant women. Thus, Tofacitinib is not advisable to be used during pregnancy. Please consult your doctor.
Driving Generally Safe
Tofacitinib usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
Dose adjustment is needed in patients with moderate kidney impairment. It is not advisable to be used in patients with severe liver impairment.
Lactation Not Advisable
Animal studies have shown the excretion of Tofacitinib in animal milk but it is unknown in human milk. Thus, Tofacitinib is not advisable to be used during breastfeeding. Please consult your doctor.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
