Venlafaxine

Uses of Venlafaxine

Venlafaxine is commonly used to treat Anxiety Disorder, Depression and Panic Disorder.

How Venlafaxine Works

The exact mechanism of Venlafaxine is still not known, but it is hypothesized that Venlafaxine and its metabolite, O-desmethylvenlafaxine are potent serotonin and noradrenaline reuptake inhibitor (SNRI) and weak dopamine reuptake inhibitor. This mechanism can potentiate the action of neurotransmitters which are found low in conditions such as depression.

Side Effects of Venlafaxine

Decreased appetite, Confusional state, Libido decreased, Nervousness, Insomnia, Abnormal dreams, Sleepiness, Visual disturbance, Tinnitus, Palpitation, Increased blood pressure, Altered bowel habit, Increased blood cholesterol

Warnings

Kidney Use With Care

Dose adjustment may be needed in patients with severe kidney impairment and patients requiring haemodialysis.

Alcohol Not Advisable

Venlafaxine is a CNS-active substance which should be avoided taking simultaneously with alcohol.

Pregnancy Not Safe

Animal studies have shown reproductive toxicity but there are no adequate data of potential risks on pregnant women. Thus, Venlafaxine is not advisable to be used during pregnancy unless the benefits outweigh the risks.

Driving Not advisable

Do not drive unless you are feeling well. Venlafaxine may cause side effects such as impaired judgement, thinking and motor skills, all of which could affect your ability to concentrate and drive.

Liver Use With Care

Dose adjustment may be needed in patients with mild to moderate liver impairment. Caution use needs to be practised in patients with severe liver impairment as there are limited data in this group of patient.

Lactation Not Advisable

Venlafaxine and its metabolite are found to be secreted in human milk which has been reported to cause irritability and abnormal sleep patterns in breastfed babies. Thus, the decision has to be made whether to discontinue the medication or breastfeeding based on the benefit-risk ratio. Please consult your doctor.

Frequently Asked Questions

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).