Vigabatrin
Uses of Vigabatrin
Vigabatrin is commonly used to treat Epileptic seizures
How Vigabatrin Works
Vigabatrin is an anticonvulsant which acts by increasing the level of the inhibitory neurotransmitter, Gamma-aminobutyric acid (GABA) and suppress the repetitive neuronal firing by inhibiting the voltage-sensitive sodium channels. Thus, it helps in relieving the convulsion during seizures.
Side Effects of Vigabatrin
Drowsiness, Fatigue, Irritability, Headache, Neurological disturbance, Visual disturbance, Gut disturbance, Liver dysfunction
Warnings
Kidney Use With Care
Dose adjustment and caution use may be needed in patients with kidney impairment.
Alcohol Not Advisable
There is no known interaction between Vigabatrin and alcohol but alcohol may worsen the progression of epilepsy. Thus, the use of alcohol is not recommended in patients with epilepsy.
Pregnancy Not Safe
Animal studies have shown reproductive toxicity but there are limited data showing the risk of Vigabatrin use during pregnancy due to the presence of concomitant antiepileptics. Thus, Vigabatrin is not advisable to be used during pregnancy unless the benefits outweigh the risks. Please consult your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Vigabatrin may cause side effects such as drowsiness or visual disturbance, all of which could affect your ability to concentrate and drive.
Liver Limited Data
Vigabatrin is safe to use in patients with liver impairment.
Lactation Limited Data
Vigabatrin is known to be secreted in human milk but there is limited data on the effects on breastfed babies. Thus, the decision on discontinuing breastfeeding or the medication should be made. Please consult your doctor.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
