Ziprasidone

Uses of Ziprasidone

Ziprasidone is commonly used to treat Mania, Schizophrenia

How Ziprasidone Works

Ziprasidone is an atypical antipsychotic which binds strongly to 5-HT2A/D2 receptor which aid to relieve psychotic symptoms and mood modulation. It can also bind moderately to norepinephrine and serotonin reuptake sites which may contribute to relieving anxiety.

Side Effects of Ziprasidone

Sleepiness, Rash, Stomach disturbances, Neurological disturbances, Weight gain, Extrapyramidal symptoms, Tardive dyskinesia, Hyperglycemia, Sexual dysfunction

Warnings

Kidney Use With Care

Dose adjustment is needed for patients with kidney impairment.

Alcohol Not Advisable

It is unsafe to consume alcohol with Ziprasidone. Taking Ziprasidone with alcohol may have additive effects in sleepiness and neurological disturbances.

Pregnancy Not Safe

Ziprasidone usage is not advisable during pregnancy as animal studies have shown potential risks on the foetus. It can only be used when the benefits outweigh the risks. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Ziprasidone may cause side effects such as sleepiness, impairment of judgement, thinking or motor skills, all of which could affect your ability to concentrate and drive.

Liver Limited Data

Ziprasidone is safe to use in patients with liver impairment.

Lactation Limited Data

Ziprasidone safety during breastfeeding is not well established. It can only be used when the benefits outweigh the risks. Please consult your doctor.

Frequently Asked Questions

Written by , MD (Universiti Hasanuddin, Indonesia)

Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).