Zonisamide
Uses of Zonisamide
Zonisamide is commonly used to treat Epilepsy
How Zonisamide Works
Zonisamide is a sulfonamide so it seems to not relate to any seizure medications. However, it has an unknown mechanism for controlling epilepsy. It is hypothesized to block sodium and voltage-sensitive calcium channels which will then prevent neuronal depolarization that helps in controlling partial seizure.
Side Effects of Zonisamide
Abdominal pain, Altered bowel habit, Dry mouth, Taste disturbance, Headache, Dizziness, Rash, Neurological disturbance
Warnings
Kidney Use With Care
Dose adjustment is required for patient with kidney impairment. Its usage is not advisable in patients with severe kidney impairment (GFR <50mL/min).
Alcohol Not Advisable
It is unsafe to consume alcohol with Zonisamide. Taking Zonisamide with alcohol may have additive effects on causing dizziness, drowsiness and difficulty concentrating.
Pregnancy Not Safe
Zonisamide may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies showing potential risks. The use of Zonisamide is not advisable during pregnancy unless clearly necessary. Please consult your doctor.
Driving Not advisable
There are no studies of Zonisamide on the effect of ability to drive. Do not drive unless you are well.
Liver Use With Care
Dose adjustment of Zonisamide is required for patient with liver impairment. Its usage is not advisable in patients with severe liver impairment.
Lactation Not Advisable
Zonisamide is shown to be excreted in human milk and may pose potential risks to breastfed babies. A decision must be made whether to discontinue breastfeeding or discontinue Zonisamide. Please consult your doctor.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
