Acetaminophen
Uses of Acetaminophen
Paracetamol is commonly used to treat joint pain, dental pain, fever, headache, migraine, muscle pain, pain during menstruation and post-operative pain.
How Acetaminophen Works
Paracetamol is an analgesic. It blocks the generation of pain impulses peripherally. It causes an antipyretic effect through inhibition of the hypothalamic heat-regulating center. The weak anti-inflammatory effect is due to inhibition of prostaglandin synthesis in the central nervous system.
Side Effects of Acetaminophen
Leucopenia, Thrombocytopenia, Pancytopenia, Angioedema, Nausea, Vomiting, Constipation, Headache, Insomnia, Hypotension .
Warnings
Kidney Use With Care
It is advisable to use Acetaminophen with caution in patients with severe renal impairment.
Alcohol Safe
It is safe to consume alcohol in small amount while taking Acetaminophen. Large quantities of alcohol may increase the risk of liver side effects.
Pregnancy Maybe Safe
There is no effect in pregnancy if Acetaminophen is used as the recommended dosage.
Driving Generally Safe
Acetaminophen usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
It is advisable to use Acetaminophen with caution in patients with severe liver impairment. The effects of overdose are greater in patients with non-cirrhosis alcoholic liver disease. Delayed in treatment of overdose may also cause serious damage to the liver.
Lactation Not safe - high risk
Acetaminophen is excreted in human breast milk in very small amount, therefore it is safe to use Acetaminophen during breastfeeding.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
