Amiloride + Hydrochlorothiazide
Uses of Amiloride + Hydrochlorothiazide
The combination of Amiloride and Hydrochlorothiazide belongs to the class of diuretics and is indicated for the treatment of hypertension and edema associated with congestive heart failure, cirrhosis of the liver, and nephrotic syndrome.
How Amiloride + Hydrochlorothiazide Works
Amiloride inhibits sodium reabsorption in the distal tubules of the kidneys, reducing potassium excretion. Hydrochlorothiazide enhances diuresis by inhibiting sodium reabsorption, leading to increased water and sodium excretion, albeit with potassium loss. Together, they create a synergistic effect for managing hypertension and edema.
Side Effects of Amiloride + Hydrochlorothiazide
Dizziness, Headache, Nausea, Vomiting, and Increased Blood Potassium Levels.
Warnings
Kidney Use With Care
Amiloride + Hydrochlorothiazide has potential side effect on the kidney as it has medium diuretic effect. However, this drug should be used with caution if combined with other diuretics as it may cause hyperkalemia. Amiloride + Hydrochlorothiazide is contraindicated in renal failure.
Alcohol Not Advisable
It is not advisable to take Amiloride + Hydrochlorothiazide with alcohol as it may enhance the effect of lightheadedness, low blood pressure, headache, and dizziness.
Pregnancy Maybe Safe
Studies on animal reproduction have failed to demonstrate any risk to the fetus and there are no adequate studies in pregnant women regarding Amiloride + Hydrochlorothiazide.
Driving Not advisable
Do not drive unless you are feeling well. Amiloride + Hydrochlorothiazide may cause side effects such as reduced mental alertness which could affect the ability to concentrate and drive.
Liver Use With Care
Amiloride + Hydrochlorothiazide should be used with caution in patients with pre-existing liver disease
Lactation Limited Data
There is limited data on the safety of Amiloride + Hydrochlorothiazide for breastfeeding. However, the excessive diuretic effect may cause lactation suppression which usage of amiloride alone may not be able to cause this effect.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
