Azathioprine
Uses of Azathioprine
Azathioprine is commonly used to treat Autoimmune diseases such as Nephrotic syndrome associated with Lupus Nephritis and Rheumatoid Arthritis, Prevention Of Organ Rejection In Transplant Patients
How Azathioprine Works
Azathioprine inhibits RNA, DNA and purine synthesis and coenzyme function and formation. Thus, it interferes with cellular metabolism and mitosis rendering the immunosuppressive effect.
Side Effects of Azathioprine
Headache, Restlessness, Ireegular Heartbeat, Hallucination, Difficulty In Urination,Paralytic Ileus
Warnings
Kidney High Risk
Azathioprine's toxicity may be enhanced in patients with renal impairment but no controlled studies have supported this statement. Dose adjustment Azathioprine may be needed with haematological monitoring. Please consult your doctor.
Alcohol Safe
It is safe to consume alcohol with Azathioprine as there is no interaction between them.
Pregnancy Not Safe
Azathioprine is unsafe to use during pregnancy. Human and animal studies have shown adverse effects on the fetus such as low birth weight, premature birth and spontaneous abortion. There is also evidence of haematological disorder in neonates whose mother took Azathioprine.
Driving Limited Data
Azathioprine's influence on ability to drive is unknown. Nevertheless, do not drive unless you are feeling well.
Liver Use With Care
Azathioprine is metabolised in the liver. Thus, dose adjustment of Azathioprine may be needed with liver impairment. Please consult your doctor.
Lactation Not Advisable
Azathioprine metabolites such as 6-Mercaptopurine is found in colostrum and breast milk in women receiving the treatment. Thus, Azathioprine should be avoided in lactating women.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
