Baclofen
Uses of Baclofen
Baclofen is commonly used to treat Muscle spasticity, Hiccups, Nerve Pain, GERD and Alcoholic liver disease
How Baclofen Works
Baclofen acts by inhibiting both monosynaptic and polysynaptic reflexes in the spinal cord. This is achieved by hyperpolarisation of the primary afferent neurones resulting in muscle relaxation.
Side Effects of Baclofen
Nausea, Somnolence, Lightheadedness, Dizziness, Fatigue, Confusion, Headache, Ear ringing, Slurred speech, Dry mouth
Warnings
Kidney Use With Care
Patient with mild to moderate renal impairment will be needing dose adjustment while the use in severe renal impairment need a specialist evaluation to weigh in the potential benefit and risk.
Alcohol Not Advisable
It is not advisable to consume alcohol and Baclofen together as the depressant additive effects of central nervous system can be augmented.
Pregnancy Not Safe
Human pregnancy data have been showing some adverse effects on the newborn baby as Baclofen does cross the placenta. However, teratogenicity and fetal toxicity has not been reported. Use of Baclofen should be weighted if the benefit outweighs the risk.
Driving Not advisable
It is not advisable to drive or operate machinery when taking Baclofen due to side effects such as dizziness and headache which can affect the ability to concentrate.
Liver Limited Data
There are no proper studies involving Baclofen and patient with hepatic impairment. Liver is not involve majorly in Baclofen metabolism but may elevate liver enzymes. Caution should be taken when taking Baclofen in a patient with hepatic impairment.
Lactation Limited Data
Baclofen is present in the human breastmilk. Breastfeeding can be continued if the concentration of Baclofen is low but precautionary measure should be taken.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
