Betahistine
Uses of Betahistine
Betahistine is commonly used in the treatment of Meniere's disease and treating vertigo.
How Betahistine Works
Betahistine is an antivertigo drug. It works by improving the microcirculation in the labyrinth, thus reducing endolymphatic pressure.
Side Effects of Betahistine
Nausea, Dyspepsia, Headache, Drowsiness, Rash, Pruritus, Steven-Johnson syndrome, Urticaria, Hypotension, Paresthesia
Warnings
Kidney Safe If Prescribed
Betahistine is excreted in the urine. However, renal excretion of Betahistine itself is of minor importance because about 85% of the original dose is recovered in the urine for the dose range between 8 and 48 mg as inactive metabolites
Alcohol Not Advisable
It is not recommended to consume alcohol with Betahistine because there is a case report of an interaction with ethanol. However, there is limited data to suggest the specific side effects that can occur if alcohol was taken together with Betahistine.
Pregnancy Maybe Safe
Betahistine may be safe to use during pregnancy. A test done in pregnant rabbits have shown no teratogenic effect, however, limited data obtained in human studies. Due to unknown effects, pregnant women are advised to avoid Betahistine. Please consult your doctor before use.
Driving Generally Safe
Betahistine usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Limited Data
Betahistine should be used with caution in patients with liver disease because Betahistine is mainly being metabolised by the liver. Dose adjustment of Betahistine may be needed. Please consult your doctor.
Lactation Limited Data
Betahistine should not be used during breastfeeding. No studies have been done to prove the excretion of Betahistine in both humans and animals milk. As precautionary measures, Betahistine should not be used during breastfeeding due to the insufficient information.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
