Canagliflozin
Uses of Canagliflozin
Canagliflozin is commonly used in the treatment of Type 2 Diabetes Mellitus
How Canagliflozin Works
Canagliflozin acts on sodium-glucose co-transporter 2 (SGLT-2) in the proximal convoluted tubule which filtered glucose reabsorption. It inhibits the SGLT-2 thus reduces the reabsorption of glucose and increases the excretion of glucose in the urine.
Side Effects of Canagliflozin
Dry mouth, Hypovolemia, Urinary tract infection, Angioedema, Rash, Decrease bone mineral density
Warnings
Kidney Use With Care
Canagliflozin's efficacy is dependant on renal function. It is not suitable for a patient with severe renal impairment. Dose adjustment also may be needed depending on the renal function.
Alcohol Not Advisable
Alcohol may affect blood sugar levels in a diabetic patient. Therefore it is not advised to drink alcohol while taking this medication.
Pregnancy Not Safe - High Risk
Canagliflozin should not be used in pregnant women. It should be discontinued if prescribed to a pregnant lady prior to pregnancy.
Driving Generally Safe
Only drive if you are feeling well. Canagliflozin is less likely to impair your concentration, however, it may cause hypoglycemia when used with Canagliflozin or sulfonylureas. It also can cause hypovolemia which may present as hypotension.
Liver Use With Care
No adjustment needed in a patient with mild or moderate liver impairment. However, it is not recommended to be used in patients with severe renal impairment.
Lactation Not Advisable
Studies in animals have shown that Canagliflozin may be excreted in breastmilk and may carry a potential risk to newborns or infants. This medication should not be used in breastfeeding mothers.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
