Carbamazepine
Uses of Carbamazepine
Carbamazepine is commonly used to treat Epilepsy, Epileptic seizures, Mania, Seizures and Trigeminal Neuralgia
How Carbamazepine Works
Carbamazepine works by limiting the sodium influx into the neuronal membranes which decrease the activity of the thalamus and temporal stimulation which leads to decreased neural discharge, thus reduce the occurrence of epilepsy.
Side Effects of Carbamazepine
Dizziness, Drowsiness, Loss of balance, Dry mouth, Vomiting, Abdominal pain, Headache, Impotence, Breast enlargement, Jaundice
Warnings
Kidney Use With Care
Carbamazepine should be used with caution in people with renal impairment. Dosage adjustment may be needed to avoid toxicity and prolong adverse reaction of the medication.
Alcohol Not Advisable
Alcohol can exacerbate the effects of Carbamazepine such as drowsiness and dizziness.
Pregnancy Not Safe
There is proven data regarding the adverse effects of Carbamazepine on the development of fetus. The use of Carbamazepine has to weigh the risk and benefits of the mother and developing fetus.
Driving Not advisable
It is not recommended to drive while taking this medication as the side effects such as drowsiness and dizziness may reduce your ability to drive and operating machines. Only drive if you are feeling well.
Liver Limited Data
Carbamazepine undergoes extensive hepatic metabolism and as such dosage adjustment is recommended in those with hepatic impairment.
Lactation Limited Data
Carbamazepine is found in human breastmilk and has been associated with some adverse effects on the health of the infant. The decision of continuing the treatment or breastfeeding should be weighted by the specialists taking into consideration or the risk and benefit for the mother and the infant.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
