Ceftazidime
Uses of Ceftazidime
Ceftazidime is commonly used to treat Bacterial Infections, Typhoid Fever
How Ceftazidime Works
Ceftazidime works by binding to the Penicillin-Binding Proteins to inhibit the final step of transpeptidation of the peptidoglycan synthesis of the bacterial cell wall. This results in failure of cell wall synthesis which ultimately leads to the death of the bacteria.
Side Effects of Ceftazidime
Metallic taste, Headache, Dizziness, Diarrhea, Nausea, Vomiting, Abdominal pain, Itchiness, Skin rash, Fever, Allergic reaction
Warnings
Kidney Use With Care
Ceftazidime is excreted by the kidneys and dosage adjustment is advisable for people with renal impairment.
Alcohol Safe
There is no contraindication on the consumption of alcohol with Ceftazidime suggested by any previous clinical data.
Pregnancy Maybe Safe
Animal studies have been shown to be safe for fetal development but no adequate data to suggest the same on human pregnancy study or to suggest harm either. Caution should be taken when commencing someone on Ceftazidime during pregnancy.
Driving Not advisable
It is not advisable to drive or operate machinery when taking Ceftazidime due to its potential side effects such as dizziness and headache which can affect concentration and ability to drive.
Liver Safe If Prescribed
There is no dosage adjustment or contraindication for people with hepatic impairment according to the manufacturer labelling. However, close clinical monitoring is advisable.
Lactation Safe If Prescribed
Ceftazidime is excreted into the human breastmilk and it is not anticipated to cause the infant any harm when Cetazidime is given at therapeutic dose to the mother. It is, therefore, can be used during breastfeeding.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
