Ceritinib
Uses of Ceritinib
Ceritinib is commonly used to treat ALK-positive Non-Small Cell Lung Cancer
How Ceritinib Works
Ceritinib works by inhibiting the anaplastic lymphoma kinase (ALK) of the non-small cell lung cancer. It resulted in decreased protein signalling thus reduces the proliferation of ALK-dependent cancer cells.
Side Effects of Ceritinib
Blurred vision, Vision impairment, Nausea, Vomiting, Diarrhea, Difficulty swallowing, Stomach discomfort, Fatigue, Fever, Dizziness
Warnings
Kidney Use With Care
Ceritinib is eliminated via feces hence its effects on the kidney is negligible. No dose adjustment is needed on mild to moderate renal impairment patient but careful monitoring is advisable for severe renal impairment patients.
Alcohol Safe
There is no contraindication on the consumption of alcohol with Ceritinib suggested by any previous clinical data. However, the side effects of alcohol may worsen the adverse reaction of Ceritinib and caution should be taken by the user.
Pregnancy Not Safe
Animal reproductive studies have been shown potential harm to the development of the fetus. Due to its potential harm to human pregnancy, it is not advisable to be used during pregnancy and effective contraception should be considered in women of child-bearing potential.
Driving Not advisable
It is not advisable to drive or operate machinery when taking Ceritini due to its potential side effects such as dizziness and eye disorders which can affect concentration and ability to drive.
Liver Limited Data
Dosage adjustment is advisable for severe hepatic impairment patients due to its potential serious side effects.
Lactation Limited Data
It is not known whether Ceritinib will be excreted into human breastmilk or not and it is advisable not to breastfeed the infant during treatment period due to its potential adverse effects.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
