Chlorambucil
Uses of Chlorambucil
Chlorambucil is commonly used to treat Hodgkin's Disease, Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukaemia, Waldenstrom Macroglobulinaemia
How Chlorambucil Works
Chlorambucil works by interfering with DNA replication and RNA transcription by alkylation and cross-linking of the cellular DNA strands. This causes the disruption of nucleic acid function which in turn causing the production of defective cancer cells.
Side Effects of Chlorambucil
Infertility, Numbness, Nausea, Vomiting, Loss of appetite, Rash, Jaundice, Seizures, Oral ulcer, Abdominal pain
Warnings
Kidney Use With Care
Dosage adjustment is not needed when Chlorambucil is used in patients with renal impairment. However, close monitoring is advisable.
Alcohol Safe
There is no contraindication on the consumption of alcohol with Chlorambucil suggested by any previous clinical data.
Pregnancy Not Safe
Chlorambucil is contraindicated in pregnancy due to its potential reproductive side effects and in women of child-bearing age, effective contraception is advisable.
Driving Generally Safe
It is not known whether Chlorambucil will affect the ability to drive or not. It is advisable not to drive if the patient experience side effects which can cause impairment in the ability to drive.
Liver Use With Care
Dosage adjustment and close monitoring are advisable for people with hepatic impairment.
Lactation Not Advisable
It is not known whether Chlorambucil will be excreted into human breastmilk or not and it is advisable not to breastfeed the infant during treatment period due to its potential adverse effects.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
