Conjugated Estrogens
Uses of Conjugated Estrogens
Conjugated estrogens are commonly used to treat vaginal dryness, failure of ovarian development, postmenopausal osteoporosis, prostate cancer, and pain due to menopause. It is also being used as contraception and hormone replacement therapy.
How Conjugated Estrogens Works
Conjugated estrogens comprise of a mixture of synthetic sex hormones. Following menopause, these hormones replace the production of estrogen and relieve menopausal symptoms. It is also used to prevent bone loss after menopause or oophorectomy.
Side Effects of Conjugated Estrogens
Increased risk of breast, endometrial and ovarian cancers, Abdominal pain, Diarrhea, Dyspepsia, Back pain, Edema, Weight gain/loss, Arthralgia, Headache, Breakthrough bleeding, Depression
Warnings
Kidney Use With Care
Conjugated Estrogens should be used with caution in patients with renal impairment as estrogens may cause fluid retention. Such patients also require close observation.
Alcohol Safe
There is no identifiable risk between consumption of alcohol and Conjugated Estrogens.
Pregnancy Not Safe - High Risk
It is unsafe to use Conjugated Estrogens during pregnancy. Both animal and human studies have shown that it may cause fetal abnormalities and the risks to the fetus outweigh the benefits of therapy to mother.
Driving Generally Safe
Conjugated Estrogens usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
Conjugated Estrogens are contraindicated in patients with acute liver disease or history of liver diseases.
Lactation Not Advisable
It is not safe to use Conjugated Estrogens during breastfeeding. The presence of estrogens in breast milk may reduce the production of milk.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
