Danazol
Uses of Danazol
Danazol is commonly used to treat Benign Fibrocystic Breast Disease, Endometriosis, Heavy Menstrual Bleeding and hereditary angioedema.
How Danazol Works
Danazol inhibits the pituitary secretion of FSH and LH, resulting in atrophy of normal and ectopic endometrial tissue. It also decreases the growth rate of abnormal breast tissues and reduces attacks of hereditary angioedema by increasing C4 levels of the complement system.
Side Effects of Danazol
Androgenic effects (e.g. acne, seborrhoea, wt gain, hair loss, voice change, clitoral hyperthrophy), Emotional lability, Headache, Increased heart rate, Vaginal irritation, Abnormal semen quality, Menstrual disturbances, Rash.
Warnings
Kidney Use With Care
Danazol should be used with care in patients with kidney disease. Dose adjustment and monitoring of renal function is required. Please consult your doctor before using it.
Alcohol Not Advisable
It is not recommended to consume alcohol with Danazol as it can cause side effects of shortness of breath.
Pregnancy Not Safe - High Risk
Both human and animal studies demonstrated adverse effects of Danazol on the fetus in a pregnant woman. It is not recommended for use during pregnancy. Please consult your doctor before using it.
Driving Generally Safe
Danazol cause no side effects which could affect your concentration and on your ability to drive.
Liver Use With Care
Danazol should be used with care in patients with liver disease. Dose adjustment and monitoring of liver function is required. Please consult your doctor before using it.
Lactation Not Advisable
Danazol is best avoided during lactation. It is excreted into human milk and could cause androgenic effect on a nursing baby. Please consult your doctor before using it.