Dapagliflozin
Uses of Dapagliflozin
Dapagliflozin is commonly used in the treatment of Type 2 Diabetes Mellitus.
How Dapagliflozin Works
Dapagliflozin, an antidiabetic drug which is a reversible inhibitor of sodium-glucose co-transporter 2 that works by reducing the reabsorption of filtered glucose and lowers the renal threshold of glucose. Hence, it leads to increase of urinary glucose excretion.
Side Effects of Dapagliflozin
Nausea, Constipation, Thirst, Dry mouth, Back pain, Dizziness, Urticaria, Hypoglycemia, Dysuria, Rash, Vaginitis/balanitis, Urinary Tract Infection
Warnings
Kidney High Risk
Dapagliflozin is contraindicated in patients with moderate to severe renal impairment and patients on dialysis. This is because the glycemic efficacy of the drug depends on renal function. Dose adjustment of Dapagliflozin and monitoring of renal function is necessary. Please consult your doctor.
Alcohol Safe
There is no known interaction of Dapagliflozin with alcohol.
Pregnancy Not Safe
Dapagliflozin may be unsafe to use during pregnancy. Animal reproduction studies have shown adverse effects on the fetus. However, there are limited well-controlled human studies. The benefits from the use of Dapagliflozin in pregnant women may be acceptable despite the risk. Please consult your doctor.
Driving Generally Safe
Dapagliflozin usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Use With Care
Dapagliflozin should be used with caution in patients with severe liver impairment. Dose adjustment of Dapagliflozin may be needed. Please consult your doctor.
Lactation Not Advisable
Dapagliflozin is contraindicated during lactation. Animal studies have shown excretion of Dapagliflozin in milk.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
