Dasabuvir
Uses of Dasabuvir
Dasabuvir is commonly used to treat chronic Hepatitis C infection.
How Dasabuvir Works
Dasabuvir is a non-nucleoside inhibitor of the HCV RNA-dependent RNA polymerase, which is important for the virus to multiply and survive in an infected person.
Side Effects of Dasabuvir
Anaemia, Insomnia, Nausea, Diarrhea, Vomiting, Pruritus, Asthenia, Lethargy
Warnings
Kidney Safe If Prescribed
Dasabuvir metabolism occurs in the kidney. However, the changes in Dasabuvir exposures in users with varying degrees of renal impairment is not significant and therefore doesn't require dose adjustment. Please do inform your doctor if you have underlying comorbidity.
Alcohol Safe
Taking Dasabuvir together with alcohol may cause interactions to occur but no proven research indicates so. Please consult your doctor before using it.
Pregnancy Limited Data
Animal studies have failed to reveal evidence of teratogenicity but it has not been tested on individuals who are conceiving. It is best to avoid taking it during pregnancy. Please consult your doctor before using it.
Driving Generally Safe
Dasabuvir has negligible effect on your ability to concentrate and drive. You are allowed to drive unless you feel fatigued.
Liver Limited Data
Dasabuvir should be used with caution in patients with liver disease. Dose adjustment of Dasabuvir is not required in patients with mild liver disease but it is contraindicated in moderate to severe liver disease. Please do inform your doctor if you have underlying comorbidity.
Lactation Limited Data
Dasabuvir is excreted into the animal milk but its excretion in human milk is unknown or very low. Developmental and health benefits of breastfeeding to child should be considered as well as the mother's clinical need for this product.
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
