Diphenoxylate
Uses of Diphenoxylate
Diphenoxylate is commonly used in the treatment of diarrhea
How Diphenoxylate Works
Diphenoxylate is an Antidiarrheals Diphenoxylate works by affecting the smooth muscles of the intestinal tract where it causes slowing down of the intestinal motility and reduces the excessive GI propulsion.
Side Effects of Diphenoxylate
Headache, Drowsiness, Dizziness, Restlessness, Euphoria, Depression, Numbness of the extremities, Hypersensitivity reaction, Gum swelling
Warnings
Kidney Safe If Prescribed
Diphenoxylate is safe to be used in patients with kidney disease and no dosage adjustment required. However, please consult your doctor.
Alcohol Not Advisable
It is not advisable to take alcohol with Diphenoxylate as it would potentiate effects of CNS depressants
Pregnancy Not Safe
Diphenoxylate may be unsafe to use during pregnancy. Animal studies have shown side effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable even with the risk. Please consult your doctor.
Driving Not advisable
Do not drive unless you are feeling well. Diphenoxylate may cause side effects such as dizziness, drowsiness or numbness, all of which could affect the ability to concentrate and drive.
Liver Use With Care
Diphenoxylate should be used with caution in patients with liver disease. Dose adjustment of Diphenoxylate may be needed. Please consult your doctor.
Lactation Not Advisable
Diphenoxylate is shown to be excreted in breast milk. It is not advisable for women to breastfeed while consuming Diphenoxylate because of its potential adverse effects on infants.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
