Domperidone
Uses of Domperidone
Domperidone is commonly used to treat gastrointestinal symptoms such as heartburn, indigestion, nausea, and vomiting.
How Domperidone Works
Domperidone is an anti-emetic drug and it works by increasing oesophageal peristalsis, improving gastroduodenal coordination and lowering sphincter pressure, gastric motility and peristalsis. All these action aid gastric emptying and reduces small intestine transit time.
Side Effects of Domperidone
Diarrhea, Dry mouth, Amenorrhea, Breast pain, Convulsions, Rash, Stomach cramps, Anxiety, Headache, Urinary retention
Warnings
Kidney Use With Care
Domperidone should be used with caution in patients with severe renal impairment as the elimination half-life is prolonged. Dose adjustment is also required and patients on prolonged therapy need to be monitored closely and regularly.
Alcohol Safe
There could be a possible interaction between Domperidone and alcohol. Otherwise, it is fairly safe to consume alcohol while on Domperidone.
Pregnancy Not Safe
There is limited data on human study regarding the use of Domperidone among pregnant women. Animal studies have demonstrated reproductive toxicity when it is used at a high, toxic dose. The risk for the fetus in humans is still uncertain therefore it is recommended to only use Domperidone if the benefits outweigh the potential risk to the fetus.
Driving Generally Safe
Domperidone usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Limited Data
In mild liver impairment, dose adjustment is not required however, Domperidone must be avoided in moderate to severe liver impairment.
Lactation Limited Data
Generally, Domperidone is excreted in breast milk and even though the infant only receives a small percentage of Domperidone's dose, cardiac effects remained unknown. To discontinue breastfeeding or stop taking Domperidone depends on the therapeutic benefits to mother or benefits of breastfeeding for the infant.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
