Econazole
Uses of Econazole
Econazole is commonly used to treat dandruff, fungal infections and severe fungal infections.
How Econazole Works
Econazole is an antifungal and antiparasitic. Econazole works by modifying the cell membrane permeability of cell wall membranes in fungi. It interferes with RNA and protein synthesis and lipid metabolism, hence, kills the organism presents in people with dandruff and fungal infection.
Side Effects of Econazole
Contact dermatitis, Pruritus, Erythema, Rash, Burning and stinging sensation
Warnings
Kidney Use With Care
Econazole is excreted via urine after being metabolised, however, it is poorly absorbed from skin or vagina. Thus, insignificant amount would present in the body system. Econazole is most probably safe to be used in patients with kidney disease but it should be used with caution if it is taken orally. Dose adjustment may be needed if administered orally.
Alcohol Safe
It is safe to consume alcohol with Econazole but not advisable if you apply alcohol at the same area as you apply Econazole to the skin. Both can cause skin irritation that may worsen the effects.
Pregnancy Not Safe
Econazole may be unsafe to use during pregnancy because it was proven in animal studies that Econazole have harmful effects on the fetus. However, there are limited human studies to guarantee the safety of Econazole used in pregnant women. Please consult your doctor to know your benefits from use in pregnant women is more than the risk.
Driving Generally Safe
Econazole usually does not affect the ability to drive. Do not drive unless you are feeling well.
Liver Limited Data
Liver is the main organ where metabolism of Econazole takes part. Hence, Econazole should be used with caution in patients with liver disease. Dose adjustment of Econazole may be needed if it is taken orally. However, different from oral use, Econazole is insignificant in systemic circulation if it is used topically or as vaginal pessary due to poor absorption through skin and vagina.
Lactation Limited Data
Econazole is excreted in breastmilk in a study done on rats after Econazole is administered orally. However, limited human evidence to prove the finding in the rats. Please consult your doctor to discuss the necessity of Econazole use or temporary off breastfeeding.
Frequently Asked Questions
Written by Dr Sri Viknarajan, MD (Universiti Hasanuddin, Indonesia)
Reviewed by Dr Nur Syuhada binti Zulkifli, MD, Universiti Kebangsaan Malaysia (UKM).
